Here's more evidence to support the theory that Multiple Chemical Sensitivity may be caused by an impaired ability to metabolize toxins or chemicals.
This study, published in the International Journal of Epidemiology, showed that there were significant genetic differences in people with MCS vs controls in two specific genes (CYP2D6 and NAT2) which are known to be used in the body's detoxification pathways.
Interestingly, in MCS sufferers, there is a greater chance that these genes are active. CYP2D6 is known to both activate and deactivate detox pathways, while NAT2 is involved with converting arylamines to metabolites. It is possible that when these genes are upregulated, the intermediary metabolites created may cause more symptoms than the original toxin itself.
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