GERD (Gastroesophageal Reflux Disease), where acid from the stomach goes up into the esophagus causing heartburn, affects up 20% of the adult population sometime in their life. Among those with GERD, up to 70% will have symptoms worse at night when lying down.
Treatments include: avoid trigger foods (including reducing fat and alcohol in meals), eating smaller portions, and the use of proton pump inhibitors such as Prilosec.
One interesting study found that lying on the left side might also be helpful--specially for those who feels their symptoms mostly when lying down at night.
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